With 140 athletes competing at the Royal Artillery Barracks, look out for Great Britain in the individual events and China and South Korea in the team events.
Paralympics Opening Ceremony in London will include content from competing Athletes for first time
With 4,280 athletes competing in London, we’ve chosen a select five who head into the Paralympics already having breakout years.
Judo
Russia, Azerbaijan and Great Britain will all be chasing China in 13 judo events.
Wheelchair Tennis
In London, Dutch sensation Esther Vergeer will try to keep her unbeaten streak of 440 matches alive as she goes for her four consecutive Paralympic singles gold.
Athletics
Take a moment to think about where you came from to get to the world’s stage.
Athletics
With some of the biggest names in Paralympic sport competing in 170 medal events, athletes on the track and field are expected to light up Olympic Stadium.
Wheelchair Basketball
London 2012 has come around faster than expected, but it is time to show the world what we all can do.
Table Tennis
Table tennis is likely to be one of the most hotly contested sports at the London 2012 Paralympic Games with hundreds of athletes participating over 10 days of enthralling action.
As the second biggest sport on the London 2012 programme, swimmers such as Australia’s Matt Cowdrey, Brazil’s Daniel Dias and Great Britain’s own Ellie Simmonds should steal the headlines.